High Prevalence of Heart Failure and Increasing Geriatric Population to Augment Growth of Congestive Heart Failure Drugs Market

 

Congestive Heart Failure Drugs Market

Congestive heart failure, the failure of the heart to pump enough blood into the body to supply the body's requirements, causes about 55,000 deaths a year in the U.S. and is responsible for another 230,000 fatalities annually. Although there have been many recent advances in congestive heart failure therapy, researchers still believe the outlook for those with this condition is still grim, with as few as half of 1% having a long life expectancy. Treatment involves improving the patient's lifestyle through exercise, diet modifications, and medications. One particular drug, methotrexate, is somewhat effective in many cases of congestive heart failure but has not proven highly effective in dealing with this condition. It is no longer recommended for use in patients younger than 60. The effects of methotrexate are seen only in elderly patients suffering from congestive heart failure who also suffer from kidney disease, hypertension, diabetes, hyperlipidemia, and severe liver disease.

Market Dynamics

High prevalence of heart failure is expected to propel growth of the congestiveheart failure drugs market. For instance, according to the study, ‘Global epidemiology and future trends of heart failure’, published in AME Medical Journal in June 2020, heart failure poses the largest burden after 60 years of age and both prevalence and YLDs have increased by 3.9% and 4.5% in very elderly people during the last 28 years. Moreover, increasing geriatric population is also expected to aid in growth of the market. For instance, according to the U.S. Census Bureau, the U.S. geriatric population is expected to reach 77 million by 2034.     

R&D of congestive heart failure drugs is expected to offer lucrative growth opportunities for players in the congestive heart failure drugs market. For instance, in November 2020, a clinical trial by Brigham and Women's Hospital and sponsored by Lexicon Pharmaceuticals, a biopharmaceutical company based in the U.S., reported that sotagliflozin, a combination sodium/glucose cotransporter 1 and 2 (SGLT1/2) inhibitor, resulted in a lower risk of the composite of deaths from cardiovascular causes, hospitalizations for heart failure, and urgent visits for heart failure than placebo.

Competitive Analysis

Major players operating in congestive heart failure drugs market include, Amgen Inc., Novartis AG, Astra Zeneca Plc., Bayer AG, Asklepios BioPharmaceutical, Gilead Sciences Inc., Glaxo Smith Kline, Pfizer Inc. and Teva Pharmaceutical Industries Ltd.

Major players operating in congestive heart failure drugs market are focused on adopting R&D to expand their product portfolio. For instance, in February 2020, Asklepios BioPharmaceutical and its NanoCor Therapeutics subsidiary announced that the first patient has been dosed in a Phase 1 clinical trial of NAN-101, a gene therapy that aims to activate protein phosphatase inhibitor 1 (I-1c) to inhibit the activity of protein phosphatase 1 (PP1), a substance that plays an important role in the development of heart failure.

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