Elypta Has Granted A US Patent For Its Liquid Biopsy Method For Cancer Metabolism Based Therapeutics Market
The advent of advanced therapies and the increasing prevalence of cancer around the globe is facilitating the growth of the global cancer metabolism-based therapeutics market. According to the International Agency for Research on Cancer, cancer is among the leading causes of death worldwide. In 2018, there were 18.1 million new cases and 9.5 million cancer-related deaths worldwide. Targeting cancer metabolism conditions is projected to serve major growth opportunities for rare drugs to treat multiple types of cancer. Changing lifestyle and growing aging population is also contributing to the risk of developing cancer among the population.
Cancer
metabolism therapy is based on the idea that tumors have a different metabolic
process from normal or healthy cells. While normal cells secrete glycogen and
glucose, cancer cells exhibit a lack of glycogen and glucose as well as
increased levels of lactic acid. Cancer patients also have a decreased ability
to use oxygen as well as an increased use of fatty acids as fuel. This
metabolite imbalance is what underlies most of the complications associated
with cancer. Cancer therapies that use various types of biological therapies
are used to directly target this metabolic disorder.
Regional
assessment reveals that, North America is estimated to gain significant growth
in the near future and this is attributed to the increasing FDA approval for
commercializing cancer metabolism-based therapeutics. For example, in September
2017, the FDA approved Agios’ and Celgene’s enasidenib for acute myeloid
leukemia (AML), validating metabolism-modulating drugs as a means of killing
cancer cells. Enasidenib (formerly AG-221) is a first-in-class inhibitor of
mutated isocitrate dehydro genase 2 (IDH2). Another instance, in August 2020,
Tyme Technologies, Inc. a biotechnology company developing cancer
metabolism-based therapies (CMBTs™) announced that the U.S. Food and Drug Administration
(FDA) has granted the company Orphan Drug Designation for its lead pipeline
candidate, SM-88 (racemetyrosine), as a treatment for patients with pancreatic cancer.
Key Developments:
1. In January 2021, Elypta has
granted a US patent for its liquid biopsy method as a cancer metabolism therapy
2. In January 2019, Drugmaker Lupin
announced that it is in the process of developing a pipeline of products under
its new drug discovery program to treat various diseases like cancer and
metabolic disorders
3. In December 2020, Rafael
Pharmaceuticals Inc. provider of cancer metabolism-based therapeutics announced
it has initiated a Phase 2 clinical trial of CPI-613® (devimistat) in
combination with hydroxychloroquine in patients with clear cell sarcoma of soft
tissue
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